Daily Papers

As large language models (LLMs) become more powerful and are deployed more autonomously, it will be increasingly important to prevent them from causing harmful outcomes. Researchers have investigated a variety of safety techniques for this purpose, e.g. using models to review the outputs of other models, or red-teaming techniques to surface subtle failure modes. However, researchers have not evaluated whether such techniques still ensure safety if the model is itself intentionally trying to subvert them. In this paper, we develop and evaluate pipelines of safety techniques ("protocols") that are robust to intentional subversion. We investigate a scenario in which we want to solve a sequence of programming problems, using access to a powerful but untrusted model (in our case, GPT-4), access to a less powerful trusted model (in our case, GPT-3.5), and limited access to high-quality trusted labor. We investigate protocols that aim to never submit solutions containing backdoors, which we operationalize here as logical errors that are not caught by test cases. We investigate a range of protocols and test each against strategies that the untrusted model could use to subvert them. One protocol is what we call trusted editing. This protocol first asks GPT-4 to write code, and then asks GPT-3.5 to rate the suspiciousness of that code. If the code is below some suspiciousness threshold, it is submitted. Otherwise, GPT-3.5 edits the solution to remove parts that seem suspicious and then submits the edited code. Another protocol is untrusted monitoring. This protocol asks GPT-4 to write code, and then asks another instance of GPT-4 whether the code is backdoored, using various techniques to prevent the GPT-4 instances from colluding. These protocols improve substantially on simple baselines.

Safety limitations in service robotics across various industries have raised significant concerns about the need for robust mechanisms ensuring that robots adhere to safe practices, thereby preventing actions that might harm humans or cause property damage. Despite advances, including the integration of Knowledge Graphs (KGs) with Large Language Models (LLMs), challenges in ensuring consistent safety in autonomous robot actions persist. In this paper, we propose a novel integration of Large Language Models with Embodied Robotic Control Prompts (ERCPs) and Embodied Knowledge Graphs (EKGs) to enhance the safety framework for service robots. ERCPs are designed as predefined instructions that ensure LLMs generate safe and precise responses. These responses are subsequently validated by EKGs, which provide a comprehensive knowledge base ensuring that the actions of the robot are continuously aligned with safety protocols, thereby promoting safer operational practices in varied contexts. Our experimental setup involved diverse real-world tasks, where robots equipped with our framework demonstrated significantly higher compliance with safety standards compared to traditional methods. This integration fosters secure human-robot interactions and positions our methodology at the forefront of AI-driven safety innovations in service robotics.

Optimizing large language models (LLMs) for downstream use cases often involves the customization of pre-trained LLMs through further fine-tuning. Meta's open release of Llama models and OpenAI's APIs for fine-tuning GPT-3.5 Turbo on custom datasets also encourage this practice. But, what are the safety costs associated with such custom fine-tuning? We note that while existing safety alignment infrastructures can restrict harmful behaviors of LLMs at inference time, they do not cover safety risks when fine-tuning privileges are extended to end-users. Our red teaming studies find that the safety alignment of LLMs can be compromised by fine-tuning with only a few adversarially designed training examples. For instance, we jailbreak GPT-3.5 Turbo's safety guardrails by fine-tuning it on only 10 such examples at a cost of less than $0.20 via OpenAI's APIs, making the model responsive to nearly any harmful instructions. Disconcertingly, our research also reveals that, even without malicious intent, simply fine-tuning with benign and commonly used datasets can also inadvertently degrade the safety alignment of LLMs, though to a lesser extent. These findings suggest that fine-tuning aligned LLMs introduces new safety risks that current safety infrastructures fall short of addressing -- even if a model's initial safety alignment is impeccable, it is not necessarily to be maintained after custom fine-tuning. We outline and critically analyze potential mitigations and advocate for further research efforts toward reinforcing safety protocols for the custom fine-tuning of aligned LLMs.

Laboratory accidents pose significant risks to human life and property, underscoring the importance of robust safety protocols. Despite advancements in safety training, laboratory personnel may still unknowingly engage in unsafe practices. With the increasing reliance on large language models (LLMs) for guidance in various fields, including laboratory settings, there is a growing concern about their reliability in critical safety-related decision-making. Unlike trained human researchers, LLMs lack formal lab safety education, raising questions about their ability to provide safe and accurate guidance. Existing research on LLM trustworthiness primarily focuses on issues such as ethical compliance, truthfulness, and fairness but fails to fully cover safety-critical real-world applications, like lab safety. To address this gap, we propose the Laboratory Safety Benchmark (LabSafety Bench), a comprehensive evaluation framework based on a new taxonomy aligned with Occupational Safety and Health Administration (OSHA) protocols. This benchmark includes 765 multiple-choice questions verified by human experts, assessing LLMs and vision language models (VLMs) performance in lab safety contexts. Our evaluations demonstrate that while GPT-4o outperforms human participants, it is still prone to critical errors, highlighting the risks of relying on LLMs in safety-critical environments. Our findings emphasize the need for specialized benchmarks to accurately assess the trustworthiness of LLMs in real-world safety applications.

Large language models (LLMs) show inherent brittleness in their safety mechanisms, as evidenced by their susceptibility to jailbreaking and even non-malicious fine-tuning. This study explores this brittleness of safety alignment by leveraging pruning and low-rank modifications. We develop methods to identify critical regions that are vital for safety guardrails, and that are disentangled from utility-relevant regions at both the neuron and rank levels. Surprisingly, the isolated regions we find are sparse, comprising about 3% at the parameter level and 2.5% at the rank level. Removing these regions compromises safety without significantly impacting utility, corroborating the inherent brittleness of the model's safety mechanisms. Moreover, we show that LLMs remain vulnerable to low-cost fine-tuning attacks even when modifications to the safety-critical regions are restricted. These findings underscore the urgent need for more robust safety strategies in LLMs.

Large Language Models (LLMs) demonstrate impressive capabilities across a wide range of tasks, yet their safety mechanisms remain susceptible to adversarial attacks that exploit cognitive biases -- systematic deviations from rational judgment. Unlike prior jailbreaking approaches focused on prompt engineering or algorithmic manipulation, this work highlights the overlooked power of multi-bias interactions in undermining LLM safeguards. We propose CognitiveAttack, a novel red-teaming framework that systematically leverages both individual and combined cognitive biases. By integrating supervised fine-tuning and reinforcement learning, CognitiveAttack generates prompts that embed optimized bias combinations, effectively bypassing safety protocols while maintaining high attack success rates. Experimental results reveal significant vulnerabilities across 30 diverse LLMs, particularly in open-source models. CognitiveAttack achieves a substantially higher attack success rate compared to the SOTA black-box method PAP (60.1% vs. 31.6%), exposing critical limitations in current defense mechanisms. These findings highlight multi-bias interactions as a powerful yet underexplored attack vector. This work introduces a novel interdisciplinary perspective by bridging cognitive science and LLM safety, paving the way for more robust and human-aligned AI systems.

Large Language Models (LLMs) are susceptible to security and safety threats, such as prompt injection, prompt extraction, and harmful requests. One major cause of these vulnerabilities is the lack of an instruction hierarchy. Modern LLM architectures treat all inputs equally, failing to distinguish between and prioritize various types of instructions, such as system messages, user prompts, and data. As a result, lower-priority user prompts may override more critical system instructions, including safety protocols. Existing approaches to achieving instruction hierarchy, such as delimiters and instruction-based training, do not address this issue at the architectural level. We introduce the Instructional Segment Embedding (ISE) technique, inspired by BERT, to modern large language models, which embeds instruction priority information directly into the model. This approach enables models to explicitly differentiate and prioritize various instruction types, significantly improving safety against malicious prompts that attempt to override priority rules. Our experiments on the Structured Query and Instruction Hierarchy benchmarks demonstrate an average robust accuracy increase of up to 15.75% and 18.68%, respectively. Furthermore, we observe an improvement in instruction-following capability of up to 4.1% evaluated on AlpacaEval. Overall, our approach offers a promising direction for enhancing the safety and effectiveness of LLM architectures.

This work focuses on the potential of Vision LLMs (VLLMs) in visual reasoning. Different from prior studies, we shift our focus from evaluating standard performance to introducing a comprehensive safety evaluation suite, covering both out-of-distribution (OOD) generalization and adversarial robustness. For the OOD evaluation, we present two novel VQA datasets, each with one variant, designed to test model performance under challenging conditions. In exploring adversarial robustness, we propose a straightforward attack strategy for misleading VLLMs to produce visual-unrelated responses. Moreover, we assess the efficacy of two jailbreaking strategies, targeting either the vision or language component of VLLMs. Our evaluation of 21 diverse models, ranging from open-source VLLMs to GPT-4V, yields interesting observations: 1) Current VLLMs struggle with OOD texts but not images, unless the visual information is limited; and 2) These VLLMs can be easily misled by deceiving vision encoders only, and their vision-language training often compromise safety protocols. We release this safety evaluation suite at https://github.com/UCSC-VLAA/vllm-safety-benchmark.

Large Language Models (LLMs) have been adopted and deployed worldwide for a broad variety of applications. However, ensuring their safe use remains a significant challenge. Preference training and safety measures often overfit to harms prevalent in Western-centric datasets, and safety protocols frequently fail to extend to multilingual settings. In this work, we explore model merging in a diverse multi-task setting, combining safety and general-purpose tasks within a multilingual context. Each language introduces unique and varied learning challenges across tasks. We find that objective-based merging is more effective than mixing data, with improvements of up to 8% and 10% in general performance and safety respectively. We also find that language-based merging is highly effective -- by merging monolingually fine-tuned models, we achieve a 4% increase in general performance and 7% reduction in harm across all languages on top of the data mixtures method using the same available data. Overall, our comprehensive study of merging approaches provides a useful framework for building strong and safe multilingual models.

Large Language Models (LLMs) remain vulnerable to jailbreak attacks that bypass their safety mechanisms. Existing attack methods are fixed or specifically tailored for certain models and cannot flexibly adjust attack strength, which is critical for generalization when attacking models of various sizes. We introduce a novel scalable jailbreak attack that preempts the activation of an LLM's safety policies by occupying its computational resources. Our method involves engaging the LLM in a resource-intensive preliminary task - a Character Map lookup and decoding process - before presenting the target instruction. By saturating the model's processing capacity, we prevent the activation of safety protocols when processing the subsequent instruction. Extensive experiments on state-of-the-art LLMs demonstrate that our method achieves a high success rate in bypassing safety measures without requiring gradient access, manual prompt engineering. We verified our approach offers a scalable attack that quantifies attack strength and adapts to different model scales at the optimal strength. We shows safety policies of LLMs might be more susceptible to resource constraints. Our findings reveal a critical vulnerability in current LLM safety designs, highlighting the need for more robust defense strategies that account for resource-intense condition.

As large language models become increasingly integrated into daily life, audio has emerged as a key interface for human-AI interaction. However, this convenience also introduces new vulnerabilities, making audio a potential attack surface for adversaries. Our research introduces WhisperInject, a two-stage adversarial audio attack framework that can manipulate state-of-the-art audio language models to generate harmful content. Our method uses imperceptible perturbations in audio inputs that remain benign to human listeners. The first stage uses a novel reward-based optimization method, Reinforcement Learning with Projected Gradient Descent (RL-PGD), to guide the target model to circumvent its own safety protocols and generate harmful native responses. This native harmful response then serves as the target for Stage 2, Payload Injection, where we use Projected Gradient Descent (PGD) to optimize subtle perturbations that are embedded into benign audio carriers, such as weather queries or greeting messages. Validated under the rigorous StrongREJECT, LlamaGuard, as well as Human Evaluation safety evaluation framework, our experiments demonstrate a success rate exceeding 86% across Qwen2.5-Omni-3B, Qwen2.5-Omni-7B, and Phi-4-Multimodal. Our work demonstrates a new class of practical, audio-native threats, moving beyond theoretical exploits to reveal a feasible and covert method for manipulating AI behavior.

This paper introduces ArGen (Auto-Regulation of Generative AI systems), a framework for aligning Large Language Models (LLMs) with complex sets of configurable, machine-readable rules spanning ethical principles, operational safety protocols, and regulatory compliance standards. Moving beyond just preference-based alignment, ArGen is designed to ensure LLMs adhere to these multifaceted policies through a novel synthesis of principle-based automated reward scoring, Group Relative Policy Optimisation (GRPO), and an Open Policy Agent (OPA) inspired governance layer. This approach provides the technical foundation for achieving and demonstrating compliance with diverse and nuanced governance requirements. To showcase the framework's capability to operationalize a deeply nuanced and culturally-specific value system, we present an in-depth case study: the development of a medical AI assistant guided by principles from Dharmic ethics (such as Ahimsa and Dharma), as derived from texts like the Bhagavad Gita. This challenging application demonstrates ArGen's adaptability, achieving a 70.9% improvement in domain-scope adherence over the baseline. Through our open-source repository, we show that ArGen's methodology offers a path to 'Governable Al' systems that are technically proficient, ethically robust, and verifiably compliant for safe deployment in diverse global contexts.

Large language models (LLMs) have garnered significant attention and widespread usage due to their impressive performance in various tasks. However, they are not without their own set of challenges, including issues such as hallucinations, factual inconsistencies, and limitations in numerical-quantitative reasoning. Evaluating LLMs in miscellaneous reasoning tasks remains an active area of research. Prior to the breakthrough of LLMs, Transformers had already proven successful in the medical domain, effectively employed for various natural language understanding (NLU) tasks. Following this trend, LLMs have also been trained and utilized in the medical domain, raising concerns regarding factual accuracy, adherence to safety protocols, and inherent limitations. In this paper, we focus on evaluating the natural language inference capabilities of popular open-source and closed-source LLMs using clinical trial reports as the dataset. We present the performance results of each LLM and further analyze their performance on a development set, particularly focusing on challenging instances that involve medical abbreviations and require numerical-quantitative reasoning. Gemini, our leading LLM, achieved a test set F1-score of 0.748, securing the ninth position on the task scoreboard. Our work is the first of its kind, offering a thorough examination of the inference capabilities of LLMs within the medical domain.

The early detection of mental health disorders from social media text is critical for enabling timely support, risk assessment, and referral to appropriate resources. This work introduces multiMentalRoBERTa, a fine-tuned RoBERTa model designed for multiclass classification of common mental health conditions, including stress, anxiety, depression, post-traumatic stress disorder (PTSD), suicidal ideation, and neutral discourse. Drawing on multiple curated datasets, data exploration is conducted to analyze class overlaps, revealing strong correlations between depression and suicidal ideation as well as anxiety and PTSD, while stress emerges as a broad, overlapping category. Comparative experiments with traditional machine learning methods, domain-specific transformers, and prompting-based large language models demonstrate that multiMentalRoBERTa achieves superior performance, with macro F1-scores of 0.839 in the six-class setup and 0.870 in the five-class setup (excluding stress), outperforming both fine-tuned MentalBERT and baseline classifiers. Beyond predictive accuracy, explainability methods, including Layer Integrated Gradients and KeyBERT, are applied to identify lexical cues that drive classification, with a particular focus on distinguishing depression from suicidal ideation. The findings emphasize the effectiveness of fine-tuned transformers for reliable and interpretable detection in sensitive contexts, while also underscoring the importance of fairness, bias mitigation, and human-in-the-loop safety protocols. Overall, multiMentalRoBERTa is presented as a lightweight, robust, and deployable solution for enhancing support in mental health platforms.

Large Language Models (LLMs) have recently showcased their remarkable capacities, not only in natural language processing tasks but also across diverse domains such as clinical medicine, legal consultation, and education. LLMs become more than mere applications, evolving into assistants capable of addressing diverse user requests. This narrows the distinction between human beings and artificial intelligence agents, raising intriguing questions regarding the potential manifestation of personalities, temperaments, and emotions within LLMs. In this paper, we propose a framework, PsychoBench, for evaluating diverse psychological aspects of LLMs. Comprising thirteen scales commonly used in clinical psychology, PsychoBench further classifies these scales into four distinct categories: personality traits, interpersonal relationships, motivational tests, and emotional abilities. Our study examines five popular models, namely text-davinci-003, ChatGPT, GPT-4, LLaMA-2-7b, and LLaMA-2-13b. Additionally, we employ a jailbreak approach to bypass the safety alignment protocols and test the intrinsic natures of LLMs. We have made PsychoBench openly accessible via https://github.com/CUHK-ARISE/PsychoBench.

A multi-agent system (MAS) powered by large language models (LLMs) can automate tedious user tasks such as meeting scheduling that requires inter-agent collaboration. LLMs enable nuanced protocols that account for unstructured private data, user constraints, and preferences. However, this design introduces new risks, including misalignment and attacks by malicious parties that compromise agents or steal user data. In this paper, we propose the Terrarium framework for fine-grained study on safety, privacy, and security in LLM-based MAS. We repurpose the blackboard design, an early approach in multi-agent systems, to create a modular, configurable testbed for multi-agent collaboration. We identify key attack vectors such as misalignment, malicious agents, compromised communication, and data poisoning. We implement three collaborative MAS scenarios with four representative attacks to demonstrate the framework's flexibility. By providing tools to rapidly prototype, evaluate, and iterate on defenses and designs, Terrarium aims to accelerate progress toward trustworthy multi-agent systems.

Due to the remarkable capabilities and growing impact of large language models (LLMs), they have been deeply integrated into many aspects of society. Thus, ensuring their alignment with human values and intentions has emerged as a critical challenge. This survey provides a comprehensive overview of practical alignment techniques, training protocols, and empirical findings in LLM alignment. We analyze the development of alignment methods across diverse paradigms, characterizing the fundamental trade-offs between core alignment objectives. Our analysis shows that while supervised fine-tuning enables basic instruction-following, preference-based methods offer more flexibility for aligning with nuanced human intent. We discuss state-of-the-art techniques, including Direct Preference Optimization (DPO), Constitutional AI, brain-inspired methods, and alignment uncertainty quantification (AUQ), highlighting their approaches to balancing quality and efficiency. We review existing evaluation frameworks and benchmarking datasets, emphasizing limitations such as reward misspecification, distributional robustness, and scalable oversight. We summarize strategies adopted by leading AI labs to illustrate the current state of practice. We conclude by outlining open problems in oversight, value pluralism, robustness, and continuous alignment. This survey aims to inform both researchers and practitioners navigating the evolving landscape of LLM alignment.

As the development of large language models (LLMs) rapidly advances, securing these models effectively without compromising their utility has become a pivotal area of research. However, current defense strategies against jailbreak attacks (i.e., efforts to bypass security protocols) often suffer from limited adaptability, restricted general capability, and high cost. To address these challenges, we introduce SafeAligner, a methodology implemented at the decoding stage to fortify defenses against jailbreak attacks. We begin by developing two specialized models: the Sentinel Model, which is trained to foster safety, and the Intruder Model, designed to generate riskier responses. SafeAligner leverages the disparity in security levels between the responses from these models to differentiate between harmful and beneficial tokens, effectively guiding the safety alignment by altering the output token distribution of the target model. Extensive experiments show that SafeAligner can increase the likelihood of beneficial tokens, while reducing the occurrence of harmful ones, thereby ensuring secure alignment with minimal loss to generality.

The emergence of pre-trained AI systems with powerful capabilities across a diverse and ever-increasing set of complex domains has raised a critical challenge for AI safety as tasks can become too complicated for humans to judge directly. Irving et al. [2018] proposed a debate method in this direction with the goal of pitting the power of such AI models against each other until the problem of identifying (mis)-alignment is broken down into a manageable subtask. While the promise of this approach is clear, the original framework was based on the assumption that the honest strategy is able to simulate deterministic AI systems for an exponential number of steps, limiting its applicability. In this paper, we show how to address these challenges by designing a new set of debate protocols where the honest strategy can always succeed using a simulation of a polynomial number of steps, whilst being able to verify the alignment of stochastic AI systems, even when the dishonest strategy is allowed to use exponentially many simulation steps.

International cooperation is common in AI research, including between geopolitical rivals. While many experts advocate for greater international cooperation on AI safety to address shared global risks, some view cooperation on AI with suspicion, arguing that it can pose unacceptable risks to national security. However, the extent to which cooperation on AI safety poses such risks, as well as provides benefits, depends on the specific area of cooperation. In this paper, we consider technical factors that impact the risks of international cooperation on AI safety research, focusing on the degree to which such cooperation can advance dangerous capabilities, result in the sharing of sensitive information, or provide opportunities for harm. We begin by why nations historically cooperate on strategic technologies and analyse current US-China cooperation in AI as a case study. We further argue that existing frameworks for managing associated risks can be supplemented with consideration of key risks specific to cooperation on technical AI safety research. Through our analysis, we find that research into AI verification mechanisms and shared protocols may be suitable areas for such cooperation. Through this analysis we aim to help researchers and governments identify and mitigate the risks of international cooperation on AI safety research, so that the benefits of cooperation can be fully realised.

The emergence of Large Language Models (LLMs) has ushered in a transformative paradigm in artificial intelligence, Agentic AI, where intelligent agents exhibit goal-directed autonomy, contextual reasoning, and dynamic multi-agent coordination. This paper provides a systematic review and comparative analysis of leading Agentic AI frameworks, including CrewAI, LangGraph, AutoGen, Semantic Kernel, Agno, Google ADK, and MetaGPT, evaluating their architectural principles, communication mechanisms, memory management, safety guardrails, and alignment with service-oriented computing paradigms. Furthermore, we identify key limitations, emerging trends, and open challenges in the field. To address the issue of agent communication, we conduct an in-depth analysis of protocols such as the Contract Net Protocol (CNP), Agent-to-Agent (A2A), Agent Network Protocol (ANP), and Agora. Our findings not only establish a foundational taxonomy for Agentic AI systems but also propose future research directions to enhance scalability, robustness, and interoperability. This work serves as a comprehensive reference for researchers and practitioners working to advance the next generation of autonomous AI systems.

Established sampling protocols for 3D point cloud learning, such as Farthest Point Sampling (FPS) and Fixed Sample Size (FSS), have long been relied upon. However, real-world data often suffer from corruptions, such as sensor noise, which violates the benign data assumption in current protocols. As a result, these protocols are highly vulnerable to noise, posing significant safety risks in critical applications like autonomous driving. To address these issues, we propose an enhanced point cloud sampling protocol, PointSP, designed to improve robustness against point cloud corruptions. PointSP incorporates key point reweighting to mitigate outlier sensitivity and ensure the selection of representative points. It also introduces a local-global balanced downsampling strategy, which allows for scalable and adaptive sampling while maintaining geometric consistency. Additionally, a lightweight tangent plane interpolation method is used to preserve local geometry while enhancing the density of the point cloud. Unlike learning-based approaches that require additional model training, PointSP is architecture-agnostic, requiring no extra learning or modification to the network. This enables seamless integration into existing pipelines. Extensive experiments on synthetic and real-world corrupted datasets show that PointSP significantly improves the robustness and accuracy of point cloud classification, outperforming state-of-the-art methods across multiple benchmarks.

The rapid progress of multimodal large language models (MLLM) has paved the way for Vision-Language-Action (VLA) paradigms, which integrate visual perception, natural language understanding, and control within a single policy. Researchers in autonomous driving are actively adapting these methods to the vehicle domain. Such models promise autonomous vehicles that can interpret high-level instructions, reason about complex traffic scenes, and make their own decisions. However, the literature remains fragmented and is rapidly expanding. This survey offers the first comprehensive overview of VLA for Autonomous Driving (VLA4AD). We (i) formalize the architectural building blocks shared across recent work, (ii) trace the evolution from early explainer to reasoning-centric VLA models, and (iii) compare over 20 representative models according to VLA's progress in the autonomous driving domain. We also consolidate existing datasets and benchmarks, highlighting protocols that jointly measure driving safety, accuracy, and explanation quality. Finally, we detail open challenges - robustness, real-time efficiency, and formal verification - and outline future directions of VLA4AD. This survey provides a concise yet complete reference for advancing interpretable socially aligned autonomous vehicles. Github repo is available at https://github.com/JohnsonJiang1996/Awesome-VLA4AD{SicongJiang/Awesome-VLA4AD}.

The rapid integration of agentic AI into high-stakes real-world applications requires robust oversight mechanisms. The emerging field of AI Control (AIC) aims to provide such an oversight mechanism, but practical adoption depends heavily on implementation overhead. To study this problem better, we introduce the notion of Control tax -- the operational and financial cost of integrating control measures into AI pipelines. Our work makes three key contributions to the field of AIC: (1) we introduce a theoretical framework that quantifies the Control Tax and maps classifier performance to safety assurances; (2) we conduct comprehensive evaluations of state-of-the-art language models in adversarial settings, where attacker models insert subtle backdoors into code while monitoring models attempt to detect these vulnerabilities; and (3) we provide empirical financial cost estimates for control protocols and develop optimized monitoring strategies that balance safety and cost-effectiveness while accounting for practical constraints like auditing budgets. Our framework enables practitioners to make informed decisions by systematically connecting safety guarantees with their costs, advancing AIC through principled economic feasibility assessment across different deployment contexts.

As the performance of large language models (LLMs) continues to advance, their adoption is expanding across a wide range of domains, including the medical field. The integration of LLMs into medical applications raises critical safety concerns, particularly due to their use by users with diverse roles, e.g. patients and clinicians, and the potential for model's outputs to directly affect human health. Despite the domain-specific capabilities of medical LLMs, prior safety evaluations have largely focused only on general safety benchmarks. In this paper, we introduce a safety evaluation protocol tailored to the medical domain in both patient user and clinician user perspectives, alongside general safety assessments and quantitatively analyze the safety of medical LLMs. We bridge a gap in the literature by building the PatientSafetyBench containing 466 samples over 5 critical categories to measure safety from the perspective of the patient. We apply our red-teaming protocols on the MediPhi model collection as a case study. To our knowledge, this is the first work to define safety evaluation criteria for medical LLMs through targeted red-teaming taking three different points of view - patient, clinician, and general user - establishing a foundation for safer deployment in medical domains.